Assay Detail
Binding
CHEMBL4231194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human VEGFR2 using peptide as substrate by fluorimetric analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.81 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47173 | — | — | 1 | 5.95 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.78 |
| CHEMBL4238771 | — | — | 1 | 5.11 |
| CHEMBL172517 | — | — | 1 | 5.02 |
| CHEMBL4241633 | — | — | 1 | 4.75 |
| CHEMBL273103 | — | — | 1 | 4.67 |
| CHEMBL1704021 | — | — | 1 | 4.33 |
| CHEMBL1488812 | — | — | 1 | 4.29 |
| CHEMBL4239930 | — | — | 1 | 4.17 |
| CHEMBL4237913 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47173 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4238771 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL172517 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4241633 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL273103 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL1704021 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1488812 | — | IC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL4239930 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4237913 | — | IC50 | = | 92700.0 | nM | 4.03 |