Assay Detail
Functional
CHEMBL4232192
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Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antiproliferative efficacy of curcumin mimics through microtubule destabilization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.68 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.38 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 5.07 |
| CHEMBL4242113 | — | — | 1 | 5.04 |
| CHEMBL1093406 | — | — | 1 | 4.97 |
| CHEMBL4246378 | — | — | 1 | 4.79 |
| CHEMBL4241131 | — | — | 1 | 4.67 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.66 |
| CHEMBL3233504 | — | — | 1 | 4.58 |
| CHEMBL3238337 | — | — | 1 | 4.51 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | 4.31 |
| CHEMBL3238332 | — | — | 1 | 4.19 |
| CHEMBL105360 | — | — | 1 | 4.04 |
| CHEMBL4250704 | — | — | 1 | - |
| CHEMBL3238335 | — | — | 1 | - |
| CHEMBL3238333 | — | — | 1 | - |
| CHEMBL4250177 | — | — | 1 | - |
| CHEMBL4238412 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 8610.0 | nM | 5.07 |
| CHEMBL4242113 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1093406 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4246378 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4241131 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL140 | CURCUMIN | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL3233504 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL3238337 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL3238332 | — | IC50 | = | 64600.0 | nM | 4.19 |
| CHEMBL105360 | — | IC50 | = | 92100.0 | nM | 4.04 |
| CHEMBL4250704 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3238335 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3238333 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4250177 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4238412 | — | IC50 | > | 100000.0 | nM | - |