Assay Detail
Binding
CHEMBL4232194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine brain tubulin polymerization measured every min for 1 hr
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiproliferative efficacy of curcumin mimics through microtubule destabilization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 6.11 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.11 |
| CHEMBL4246378 | — | — | 2 | 5.33 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.29 |
| CHEMBL1093406 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4246378 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL140 | CURCUMIN | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL1093406 | — | IC50 | = | 14390.0 | nM | 4.84 |
| CHEMBL4246378 | — | Inhibition | - | % | - |