Assay Detail
Binding
CHEMBL4232373
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Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.20 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 9.22 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.92 |
| CHEMBL28 | APIGENIN | — | 1 | 6.85 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 6.77 |
| CHEMBL9352 | NARINGENIN | — | 1 | 6.62 |
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | 6.55 |
| CHEMBL257839 | KUROMANIN | — | 1 | 6.38 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.32 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 6.31 |
| CHEMBL592005 | MALVIDIN CHLORIDE | — | 1 | 5.85 |
| CHEMBL511367 | CYANIDIN CHLORIDE | — | 1 | 5.85 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.54 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 5.47 |
| CHEMBL214381 | DIPROTIN A | — | 1 | 5.38 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | 5.33 |
| CHEMBL2165586 | ERIOCITRIN | — | 1 | 4.99 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL28 | APIGENIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL275638 | FLAVONE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL399121 | HESPERETIN | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL257839 | KUROMANIN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL44 | GENISTEIN | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL592005 | MALVIDIN CHLORIDE | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL511367 | CYANIDIN CHLORIDE | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL214381 | DIPROTIN A | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2165586 | ERIOCITRIN | IC50 | = | 10360.0 | nM | 4.99 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 10210.0 | nM | 4.99 |