Assay Detail
Functional
CHEMBL4232469
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Cytotoxicity against human U138MG cells assessed as decrease in cell viability after 72 hrs by trypan blue dye based assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U138-MG |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.40 | 9.40 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 2 | 9.40 |
| CHEMBL4248195 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4248195 | — | IC50 | = | 598000.0 | nM | - |
| CHEMBL4248195 | — | Activity | - | — | - | |
| CHEMBL308086 | DUOCARMYCIN | Activity | - | — | - |