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Assay Detail

CHEMBL4232575

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human CA9 expressed in Escherichia coli assessed as reduction in CO2 hydration by stopped flow assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 9 (CHEMBL3594)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis, structure and bioactivity of primary sulfamate-containing natural products.
Mujumdar P, Bua S, Supuran CT, Peat TS, Poulsen SA.
Bioorg Med Chem Lett (2018) 28 : 3009 -3013
PubMed 29685656 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.18 6.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3250749 1 6.84
CHEMBL471144 1 5.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3250749 Ki = 143.0 nM 6.84
CHEMBL471144 Ki = 3100.0 nM 5.51