Assay Detail
Functional
CHEMBL4233147
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of alkyl substituted pyridino[2,3-D]pyrimidine compounds as PI3Kα/mTOR dual inhibitors with improved pharmacokinetic properties and potent in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.17 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4238656 | — | — | 1 | 8.22 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.57 |
| CHEMBL4239712 | — | — | 1 | 7.51 |
| CHEMBL4250280 | — | — | 1 | 7.27 |
| CHEMBL4246481 | — | — | 1 | 7.14 |
| CHEMBL4240170 | — | — | 1 | 7.11 |
| CHEMBL4248529 | — | — | 1 | 6.73 |
| CHEMBL4246121 | — | — | 1 | 6.65 |
| CHEMBL4251185 | — | — | 1 | 6.35 |
| CHEMBL4239569 | — | — | 1 | - |
| CHEMBL4239931 | — | — | 1 | - |
| CHEMBL4244147 | — | — | 1 | - |
| CHEMBL4246923 | — | — | 1 | - |
| CHEMBL4242668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4238656 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4239712 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4250280 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4246481 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4240170 | — | IC50 | = | 77.3 | nM | 7.11 |
| CHEMBL4248529 | — | IC50 | = | 185.7 | nM | 6.73 |
| CHEMBL4246121 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL4251185 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL4239569 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4239931 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4244147 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4246923 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4242668 | — | IC50 | > | 1000.0 | nM | - |