Assay Detail

CHEMBL4233169

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ADMET

Inhibition of rabbit intestinal ACAT2

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Oryctolagus cuniculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.

Shibuya K, Kawamine K, Miura T, Ozaki C, Edano T, Mizuno K, Yoshinaka Y, Tsunenari Y.
Bioorg Med Chem (2018) 26 : 4001 -4013
PubMed 29945757 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.79	7.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL22373	CL-976	—	1	7.14
CHEMBL4249612	—	—	1	6.43

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL22373	CL-976	IC50	=	73.0	nM	7.14
CHEMBL4249612	—	IC50	=	370.0	nM	6.43