Assay Detail
Binding
CHEMBL4233172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SOAT1 in arterial homogenates isolated from 1% cholesterol fed New Zealand white rabbit assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 7.18 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4243015 | — | — | 1 | 8.40 |
| CHEMBL4238015 | — | — | 1 | 8.40 |
| CHEMBL4240947 | — | — | 1 | 8.40 |
| CHEMBL4247249 | — | — | 1 | 8.40 |
| CHEMBL4248172 | — | — | 1 | 8.30 |
| CHEMBL4245162 | — | — | 1 | 8.30 |
| CHEMBL4249787 | — | — | 1 | 8.22 |
| CHEMBL4244680 | — | — | 1 | 8.15 |
| CHEMBL4248936 | — | — | 1 | 8.15 |
| CHEMBL4239246 | — | — | 1 | 8.00 |
| CHEMBL4248950 | — | — | 1 | 7.85 |
| CHEMBL4243773 | — | — | 1 | 7.82 |
| CHEMBL4242952 | — | — | 1 | 7.82 |
| CHEMBL4241747 | — | — | 1 | 7.75 |
| CHEMBL4244693 | — | — | 1 | 7.72 |
| CHEMBL4237641 | — | — | 1 | 7.62 |
| CHEMBL4245998 | — | — | 1 | 7.62 |
| CHEMBL4246755 | — | — | 1 | 7.60 |
| CHEMBL4238468 | — | — | 1 | 7.58 |
| CHEMBL4238030 | — | — | 1 | 7.58 |
| CHEMBL4250140 | — | — | 1 | 7.58 |
| CHEMBL4242159 | — | — | 1 | 7.55 |
| CHEMBL4249263 | — | — | 1 | 7.55 |
| CHEMBL4245696 | — | — | 1 | 7.54 |
| CHEMBL4249269 | — | — | 1 | 7.54 |
| CHEMBL4245984 | — | — | 1 | 7.51 |
| CHEMBL4239138 | — | — | 1 | 7.50 |
| CHEMBL4249719 | — | — | 1 | 7.47 |
| CHEMBL4247160 | — | — | 1 | 7.46 |
| CHEMBL4242494 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4243015 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4247249 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4240947 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4238015 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4248172 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4245162 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4249787 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4244680 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4248936 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4239246 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4248950 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4243773 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4242952 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4241747 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4244693 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4237641 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4245998 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4246755 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4238468 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4238030 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4250140 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4242159 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4249263 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4245696 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4249269 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4245984 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4239138 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4249719 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4247160 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4242494 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL274185 | LECIMIBIDE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4249785 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4245518 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4250566 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4245060 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4244682 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4238769 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4249196 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4249312 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4249612 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4240484 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4249315 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4248482 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4245509 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4242889 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4241301 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4239678 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4245885 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4242551 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4241732 | — | IC50 | = | 120.0 | nM | 6.92 |