Assay Detail
ADMET
CHEMBL4233173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SOAT2 in New Zealand white rabbit intestinal microsomes assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Oryctolagus cuniculus |
| Tissue | Intestine |
| Subcellular | Microsomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 6.94 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4245162 | — | — | 1 | 7.96 |
| CHEMBL4249787 | — | — | 1 | 7.85 |
| CHEMBL4240947 | — | — | 1 | 7.75 |
| CHEMBL4238015 | — | — | 1 | 7.72 |
| CHEMBL274185 | LECIMIBIDE | 2.0 | 1 | 7.70 |
| CHEMBL4247249 | — | — | 1 | 7.68 |
| CHEMBL4243015 | — | — | 1 | 7.66 |
| CHEMBL4243773 | — | — | 1 | 7.60 |
| CHEMBL4244680 | — | — | 1 | 7.55 |
| CHEMBL4244693 | — | — | 1 | 7.54 |
| CHEMBL4248172 | — | — | 1 | 7.52 |
| CHEMBL22373 | CL-976 | — | 1 | 7.52 |
| CHEMBL4241747 | — | — | 1 | 7.52 |
| CHEMBL4248950 | — | — | 1 | 7.51 |
| CHEMBL4238468 | — | — | 1 | 7.48 |
| CHEMBL4245998 | — | — | 1 | 7.47 |
| CHEMBL4237641 | — | — | 1 | 7.44 |
| CHEMBL4248936 | — | — | 1 | 7.44 |
| CHEMBL4238030 | — | — | 1 | 7.42 |
| CHEMBL4241732 | — | — | 1 | 7.36 |
| CHEMBL4245518 | — | — | 1 | 7.36 |
| CHEMBL4245984 | — | — | 1 | 7.33 |
| CHEMBL4239246 | — | — | 1 | 7.19 |
| CHEMBL4249785 | — | — | 1 | 7.18 |
| CHEMBL4245509 | — | — | 1 | 7.13 |
| CHEMBL4242494 | — | — | 1 | 7.11 |
| CHEMBL4240484 | — | — | 1 | 7.09 |
| CHEMBL4245885 | — | — | 1 | 7.03 |
| CHEMBL4242952 | — | — | 1 | 7.03 |
| CHEMBL4242159 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4245162 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4249787 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4240947 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4238015 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL274185 | LECIMIBIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4247249 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4243015 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4243773 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4244680 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4244693 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4248172 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL22373 | CL-976 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4241747 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4248950 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4238468 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4245998 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4237641 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4248936 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4238030 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4241732 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4245518 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4245984 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4239246 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4249785 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4245509 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4242494 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4240484 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4245885 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4242952 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4242159 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4245696 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4249315 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4249719 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4249269 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4244682 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4248482 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4249612 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4242551 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4246755 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4249263 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4249196 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4250566 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4238820 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4249312 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4241301 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4247160 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4242889 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4239678 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4238382 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4238769 | — | IC50 | = | 250.0 | nM | 6.60 |