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Assay Detail

CHEMBL4233271

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Functional
Antiproliferative activity against mouse 4T1 cells after 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type 4T1
Confidence 1 — Organism
Curated By Intermediate

Target

4T1 (CHEMBL612589)
Type CELL-LINE
Organism Mus musculus

Publication

Phosphorus-containing isothiocyanate-derived mercapturic acids as a useful alternative for parental isothiocyanates in experimental oncology.
Psurski M, Janczewski Ł, Świtalska M, Gajda A, Goszczyński TM, Ciekot J, Winiarski Ł, Oleksyszyn J, Wietrzyk J, Gajda T.
Bioorg Med Chem Lett (2018) 28 : 2611 -2615
PubMed 29945793 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.66 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4246861 1 5.72
CHEMBL4248286 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4246861 IC50 = 1900.0 nM 5.72
CHEMBL4248286 IC50 = 2500.0 nM 5.60