Assay Detail
Functional
CHEMBL4233428
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Antiproliferative activity against human MDA-MB-231 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.15 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.92 |
| CHEMBL4247128 | — | — | 1 | 5.13 |
| CHEMBL4243458 | — | — | 1 | 5.04 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.98 |
| CHEMBL4243347 | — | — | 1 | 4.93 |
| CHEMBL4250891 | — | — | 1 | 4.88 |
| CHEMBL3917405 | — | — | 1 | - |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | - |
| CHEMBL4237600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4247128 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4243458 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4243347 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4250891 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3917405 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1789941 | RUXOLITINIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL4237600 | — | IC50 | > | 100000.0 | nM | - |