Assay Detail
Functional
CHEMBL4233459
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Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.74 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.21 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.14 |
| CHEMBL4248676 | — | — | 1 | 6.12 |
| CHEMBL4241141 | — | — | 1 | 6.05 |
| CHEMBL4248226 | — | — | 1 | 5.95 |
| CHEMBL4240694 | — | — | 1 | 5.91 |
| CHEMBL4237410 | — | — | 1 | 5.87 |
| CHEMBL4251261 | — | — | 1 | 5.57 |
| CHEMBL4244419 | — | — | 1 | 5.53 |
| CHEMBL4244887 | — | — | 1 | 5.45 |
| CHEMBL4248856 | — | — | 1 | 5.41 |
| CHEMBL4249316 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4248676 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4241141 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4248226 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4240694 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4237410 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4251261 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4244419 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4244887 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL4248856 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL4249316 | — | IC50 | = | 21390.0 | nM | 4.67 |