Assay Detail
Binding
CHEMBL4235015
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Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.85 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 7.51 |
| CHEMBL438139 | ROCAGLAMIDE | — | 1 | 7.16 |
| CHEMBL4204109 | — | — | 1 | 5.82 |
| CHEMBL451476 | — | — | 1 | 5.80 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 5.62 |
| CHEMBL4250573 | — | — | 1 | 5.33 |
| CHEMBL451046 | — | — | 1 | 5.27 |
| CHEMBL511805 | ALPHITOLIC ACID | — | 1 | 5.06 |
| CHEMBL23236 | BETULIN | — | 1 | 5.06 |
| CHEMBL4243911 | — | — | 1 | - |
| CHEMBL4251037 | — | — | 1 | - |
| CHEMBL4242588 | — | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL399873 | UVAOL | — | 1 | - |
| CHEMBL400074 | ERYTHRODIOL | — | 1 | - |
| CHEMBL4246020 | — | — | 1 | - |
| CHEMBL4250193 | — | — | 1 | - |
| CHEMBL1819400 | SIDEROXYLIN | — | 1 | - |
| CHEMBL4245315 | — | — | 1 | - |
| CHEMBL225303 | SYRINGALDEHYDE | — | 1 | - |
| CHEMBL227113 | LOLIOLIDE | — | 1 | - |
| CHEMBL463088 | BLUMENOL A | — | 1 | - |
| CHEMBL2392398 | — | — | 1 | - |
| CHEMBL4244962 | — | — | 1 | - |
| CHEMBL461278 | — | — | 1 | - |
| CHEMBL4247374 | — | — | 1 | - |
| CHEMBL4241991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL438139 | ROCAGLAMIDE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4204109 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL451476 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4250573 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL451046 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL511805 | ALPHITOLIC ACID | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL23236 | BETULIN | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4243911 | — | IC50 | - | — | - | |
| CHEMBL4251037 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4242588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL399873 | UVAOL | IC50 | > | 10000.0 | nM | - |
| CHEMBL400074 | ERYTHRODIOL | IC50 | > | 10000.0 | nM | - |
| CHEMBL4246020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4250193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819400 | SIDEROXYLIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL4245315 | — | IC50 | - | — | - | |
| CHEMBL225303 | SYRINGALDEHYDE | IC50 | - | — | - | |
| CHEMBL227113 | LOLIOLIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL463088 | BLUMENOL A | IC50 | > | 10000.0 | nM | - |
| CHEMBL2392398 | — | IC50 | - | — | - | |
| CHEMBL4244962 | — | IC50 | - | — | - | |
| CHEMBL461278 | — | IC50 | - | — | - | |
| CHEMBL4247374 | — | IC50 | - | — | - | |
| CHEMBL4241991 | — | IC50 | - | — | - |