Assay Detail
Binding
CHEMBL4235136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tertiary sulfonamides as potent anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4248974 | — | — | 1 | 8.70 |
| CHEMBL4246320 | — | — | 1 | 8.40 |
| CHEMBL4238053 | — | — | 1 | 8.40 |
| CHEMBL4243509 | — | — | 1 | 8.05 |
| CHEMBL4240212 | — | — | 1 | 7.92 |
| CHEMBL4244338 | — | — | 1 | 7.19 |
| CHEMBL4240141 | — | — | 1 | 7.13 |
| CHEMBL4240977 | — | — | 1 | 6.82 |
| CHEMBL4243377 | — | — | 1 | 6.80 |
| CHEMBL4243580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4248974 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4246320 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4238053 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4243509 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4240212 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4244338 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4240141 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4240977 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4243377 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4243580 | — | EC50 | > | 5000.0 | nM | - |