Assay Detail
Binding
CHEMBL4235230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat TRPV3 expressed in HEK293 cells assessed as inhibition of thymol-induced increase in intracellular calcium level pretreated for 5 mins followed by thymol addition by Fluo-4-AM dye based fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Transient receptor potential cation channel, subfamily V, member 3 (CHEMBL4295541) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.00 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4249046 | — | — | 1 | 5.10 |
| CHEMBL4238545 | — | — | 1 | 4.89 |
| CHEMBL4244422 | — | — | 1 | - |
| CHEMBL4238978 | — | — | 1 | - |
| CHEMBL4242719 | — | — | 1 | - |
| CHEMBL4241477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4249046 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4238545 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4244422 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4238978 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4242719 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4241477 | — | IC50 | > | 50000.0 | nM | - |