Assay Detail
Binding
CHEMBL4235706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER4 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor tyrosine-protein kinase erbB-4 (CHEMBL3009) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.15 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4248386 | — | — | 1 | 8.00 |
| CHEMBL4241958 | — | — | 1 | 6.82 |
| CHEMBL4237557 | — | — | 1 | 6.62 |
| CHEMBL4237800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4248386 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4241958 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4237557 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4237800 | — | IC50 | - | — | - |