Assay Detail
ADMET
CHEMBL4236264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C8 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.05 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4242598 | — | — | 1 | 7.00 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4242598 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 7900.0 | nM | 5.10 |