Assay Detail
Functional
CHEMBL4236283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Pro-apoptotic activity in human HUT78 cells after 18 hrs by caspase-Glo 3/7 assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HuT78 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 7.43 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4239232 | — | — | 1 | 8.77 |
| CHEMBL4241807 | — | — | 1 | 8.40 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.37 |
| CHEMBL4237803 | — | — | 1 | 8.31 |
| CHEMBL4250302 | — | — | 1 | 8.26 |
| CHEMBL4251203 | — | — | 1 | 8.25 |
| CHEMBL4242426 | — | — | 1 | 8.21 |
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 8.19 |
| CHEMBL4241370 | — | — | 1 | 8.14 |
| CHEMBL4246561 | — | — | 1 | 8.14 |
| CHEMBL4242292 | — | — | 1 | 8.00 |
| CHEMBL4237636 | — | — | 1 | 7.92 |
| CHEMBL4250739 | — | — | 1 | 7.92 |
| CHEMBL4240163 | — | — | 1 | 7.89 |
| CHEMBL4240635 | — | — | 1 | 7.75 |
| CHEMBL4249385 | — | — | 1 | 7.68 |
| CHEMBL4245007 | — | — | 1 | 7.58 |
| CHEMBL4248374 | — | — | 1 | 7.58 |
| CHEMBL4247370 | — | — | 1 | 7.55 |
| CHEMBL4251365 | — | — | 1 | 7.55 |
| CHEMBL4246919 | — | — | 1 | 7.50 |
| CHEMBL4238353 | — | — | 1 | 7.42 |
| CHEMBL4244362 | — | — | 1 | 7.36 |
| CHEMBL4242750 | — | — | 1 | 7.08 |
| CHEMBL4244764 | — | — | 1 | 7.01 |
| CHEMBL4251517 | — | — | 1 | 7.00 |
| CHEMBL4241014 | — | — | 1 | 6.89 |
| CHEMBL4245236 | — | — | 1 | 6.80 |
| CHEMBL4241594 | — | — | 1 | 6.77 |
| CHEMBL4244537 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4239232 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4241807 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL483254 | PANOBINOSTAT | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4237803 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4250302 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4251203 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4242426 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2105763 | QUISINOSTAT | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4241370 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4246561 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4242292 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4237636 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4250739 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4240163 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4240635 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4249385 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4245007 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4248374 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4251365 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4247370 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4246919 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4238353 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4244362 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4242750 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4244764 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4251517 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4241014 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4245236 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4241594 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4244537 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4248346 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4242086 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4238532 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4244350 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4241251 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4245840 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4249281 | — | EC50 | = | 1100.0 | nM | 5.96 |