Assay Detail
ADMET
CHEMBL4236469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal His-tagged JAK2 catalytic domain (826 to 1132 residues) expressed in baculovirus expression system using Biotin-Lyn-Substrate2 after 1 hr by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.00 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4238926 | — | — | 1 | 8.77 |
| CHEMBL4246788 | — | — | 1 | 8.30 |
| CHEMBL4242999 | — | — | 1 | 8.30 |
| CHEMBL4247874 | — | — | 1 | 7.96 |
| CHEMBL4249444 | — | — | 1 | 7.96 |
| CHEMBL4241916 | — | — | 1 | 7.82 |
| CHEMBL4239361 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4238926 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4246788 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4242999 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4247874 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4249444 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4241916 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4239361 | — | IC50 | = | 120.0 | nM | 6.92 |