Assay Detail
Functional
CHEMBL4252134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective kappa opioid antagonists for treatment of addiction, are we there yet?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 10.70 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415247 | JDTIC | 1.0 | 1 | 11.00 |
| CHEMBL511142 | BUPRENORPHINE | 4.0 | 1 | 10.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415247 | JDTIC | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL511142 | BUPRENORPHINE | Ki | = | 0.04 | nM | 10.40 |