Assay Detail
Binding
CHEMBL4252566
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Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrate after 1 to 2 hrs by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Camptothecin-psammaplin A hybrids as topoisomerase I and HDAC dual-action inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.11 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.91 |
| CHEMBL4290191 | — | — | 1 | 6.82 |
| CHEMBL4280303 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 12.44 | nM | 7.91 |
| CHEMBL4290191 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4280303 | — | IC50 | = | 253.0 | nM | 6.60 |