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Assay Detail

CHEMBL4253126

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Functional
Antioxidant activity assessed as protection against AAPH-induced DNA damage in Escherichia coli plasmid pbr322 DNA after 1 hr by agarose gel electrophoresis method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 3 — Cell-line / Tissue
Curated By Intermediate

Target

DNA (CHEMBL2364041)
Type NUCLEIC-ACID
Organism Bacteria

Publication

Novel vanillin derivatives: Synthesis, anti-oxidant, DNA and cellular protection properties.
Scipioni M, Kay G, Megson I, Kong Thoo Lin P.
Eur J Med Chem (2018) 143 : 745 -754
PubMed 29220795 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.21 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4277177 1 6.22
CHEMBL4292330 1 5.44
CHEMBL4278636 1 5.42
CHEMBL4285541 1 5.42
CHEMBL4279028 1 5.39
CHEMBL13883 VANILLIN -1.0 1 5.25
CHEMBL225303 SYRINGALDEHYDE 1 5.02
CHEMBL4278657 1 4.87
CHEMBL4293765 1 4.86
CHEMBL4283207 1 4.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4277177 IC50 = 600.0 nM 6.22
CHEMBL4292330 IC50 = 3600.0 nM 5.44
CHEMBL4278636 IC50 = 3800.0 nM 5.42
CHEMBL4285541 IC50 = 3800.0 nM 5.42
CHEMBL4279028 IC50 = 4100.0 nM 5.39
CHEMBL13883 VANILLIN IC50 = 5600.0 nM 5.25
CHEMBL225303 SYRINGALDEHYDE IC50 = 9500.0 nM 5.02
CHEMBL4278657 IC50 = 13600.0 nM 4.87
CHEMBL4293765 IC50 = 13900.0 nM 4.86
CHEMBL4283207 IC50 = 61500.0 nM 4.21