Assay Detail
Functional
CHEMBL4253143
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Antimalarial activity against liver stage of firefly luciferase-expressing Plasmodium berghei infected in human HuH7 cells measured after 48 hrs post parasite addition by luciferase-based luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Primaquine hybrids as promising antimycobacterial and antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.55 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884574 | — | — | 1 | 7.38 |
| CHEMBL3884203 | — | — | 1 | 7.13 |
| CHEMBL3330900 | — | — | 1 | 7.08 |
| CHEMBL4294203 | — | — | 1 | 6.74 |
| CHEMBL4165473 | — | — | 1 | 6.14 |
| CHEMBL3884268 | — | — | 1 | 5.73 |
| CHEMBL4161190 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884574 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3884203 | — | IC50 | = | 74.9 | nM | 7.13 |
| CHEMBL3330900 | — | IC50 | = | 82.8 | nM | 7.08 |
| CHEMBL4294203 | — | IC50 | = | 181.7 | nM | 6.74 |
| CHEMBL4165473 | — | IC50 | = | 723.8 | nM | 6.14 |
| CHEMBL3884268 | — | IC50 | = | 1873.0 | nM | 5.73 |
| CHEMBL4161190 | — | IC50 | = | 2393.3 | nM | 5.62 |