Assay Detail

CHEMBL4253148

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Functional

Cytotoxicity against human U937 cells incubated for 48 hrs by SRB assay

ChEMBL ↗

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Target

U-937 (CHEMBL612794) ↗

Open DB target context

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Primary target U-937

CHEMBL612794

Anchored from Assay target.

Protein identity U-937

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-937
Confidence	1 — Organism
Curated By	Intermediate

Target

U-937 (CHEMBL612794) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Recent advances in microtubule-stabilizing agents.

Cao YN, Zheng LL, Wang D, Liang XX, Gao F, Zhou XL.
Eur J Med Chem (2018) 143 : 806 -828
PubMed 29223097 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.96	8.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL582439	ZAMPANOLIDE	—	1	8.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL582439	ZAMPANOLIDE	IC50	=	1.1	nM	8.96