Assay Detail
Functional
CHEMBL4253251
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Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of viral RNA replication after 72 hrs by qRT-PCR method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.10 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.52 |
| CHEMBL4288160 | — | — | 1 | 6.02 |
| CHEMBL4284953 | — | — | 1 | 5.92 |
| CHEMBL4295188 | — | — | 1 | 5.74 |
| CHEMBL4277519 | — | — | 1 | 5.71 |
| CHEMBL4284464 | — | — | 1 | 5.57 |
| CHEMBL4282788 | — | — | 1 | 5.48 |
| CHEMBL4290679 | — | — | 1 | 5.47 |
| CHEMBL4284760 | — | — | 1 | 5.45 |
| CHEMBL4287865 | — | — | 1 | 5.45 |
| CHEMBL3329704 | — | — | 1 | 5.37 |
| CHEMBL4284531 | — | — | 1 | 5.31 |
| CHEMBL4277210 | — | — | 1 | 5.26 |
| CHEMBL4294487 | — | — | 1 | 5.25 |
| CHEMBL4279106 | — | — | 1 | 5.22 |
| CHEMBL4281118 | — | — | 1 | 5.22 |
| CHEMBL4291749 | — | — | 1 | 5.19 |
| CHEMBL4280929 | — | — | 1 | 5.17 |
| CHEMBL4294680 | — | — | 1 | 5.13 |
| CHEMBL4283910 | — | — | 1 | 5.09 |
| CHEMBL4292361 | — | — | 1 | 5.06 |
| CHEMBL4294082 | — | — | 1 | 4.97 |
| CHEMBL4291329 | — | — | 1 | 4.94 |
| CHEMBL4286179 | — | — | 1 | 4.94 |
| CHEMBL4291266 | — | — | 1 | 4.91 |
| CHEMBL4287266 | — | — | 1 | 4.73 |
| CHEMBL4280624 | — | — | 1 | 4.63 |
| CHEMBL4280018 | — | — | 1 | 4.55 |
| CHEMBL4280862 | — | — | 1 | 4.33 |
| CHEMBL4292816 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231813 | TELAPREVIR | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4288160 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4284953 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4295188 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4277519 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4284464 | — | EC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL4282788 | — | EC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4290679 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4284760 | — | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4287865 | — | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3329704 | — | EC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL4284531 | — | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL4277210 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4294487 | — | EC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL4281118 | — | EC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL4279106 | — | EC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL4291749 | — | EC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL4280929 | — | EC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL4294680 | — | EC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL4283910 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4292361 | — | EC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL4294082 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4291329 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4286179 | — | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4291266 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4287266 | — | EC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4280624 | — | EC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL4280018 | — | EC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL4280862 | — | EC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL4292816 | — | EC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL4287922 | — | EC50 | = | 62500.0 | nM | 4.20 |
| CHEMBL4284081 | — | EC50 | = | 68600.0 | nM | 4.16 |
| CHEMBL4283484 | — | EC50 | = | 73700.0 | nM | 4.13 |
| CHEMBL4279334 | — | EC50 | = | 80600.0 | nM | 4.09 |
| CHEMBL4292639 | — | EC50 | = | 97900.0 | nM | 4.01 |
| CHEMBL4288754 | — | EC50 | > | 166700.0 | nM | - |