Assay Detail
Binding
CHEMBL4253916
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Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phosphotyrosine protein phosphatase (CHEMBL4295521) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.66 | 6.44 |
| Ki | 1 | 5.80 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290098 | — | — | 2 | 6.44 |
| CHEMBL4279417 | — | — | 2 | 6.08 |
| CHEMBL463145 | NORARTOCARPETIN | — | 2 | 5.92 |
| CHEMBL1808155 | CHALCOMORACIN | — | 2 | 5.84 |
| CHEMBL4280952 | — | — | 2 | 5.80 |
| CHEMBL4291588 | — | — | 2 | 5.33 |
| CHEMBL220746 | CUDRAFLAVANONE A | — | 2 | 5.29 |
| CHEMBL464006 | MORUSIN | — | 2 | 5.28 |
| CHEMBL43065 | OXYRESVERATROL | — | 2 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290098 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL4290098 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4279417 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4279417 | — | IC50 | = | 831.76 | nM | 6.08 |
| CHEMBL463145 | NORARTOCARPETIN | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL463145 | NORARTOCARPETIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1808155 | CHALCOMORACIN | IC50 | = | 1445.44 | nM | 5.84 |
| CHEMBL1808155 | CHALCOMORACIN | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4280952 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4280952 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4291588 | — | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL4291588 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL220746 | CUDRAFLAVANONE A | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL220746 | CUDRAFLAVANONE A | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL464006 | MORUSIN | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL464006 | MORUSIN | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL43065 | OXYRESVERATROL | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL43065 | OXYRESVERATROL | IC50 | = | 8511.38 | nM | 5.07 |