Assay Detail
Functional
CHEMBL4254061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.67 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293027 | — | — | 1 | 4.99 |
| CHEMBL4285825 | — | — | 1 | 4.97 |
| CHEMBL4290541 | — | — | 1 | 4.84 |
| CHEMBL4277892 | — | — | 1 | 4.74 |
| CHEMBL1831157 | — | — | 1 | 4.40 |
| CHEMBL1830149 | — | — | 1 | 4.10 |
| CHEMBL4282423 | — | — | 1 | - |
| CHEMBL4292641 | — | — | 1 | - |
| CHEMBL4284762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293027 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4285825 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4290541 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4277892 | — | EC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL1831157 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1830149 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL4282423 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4292641 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4284762 | — | EC50 | > | 100000.0 | nM | - |