Assay Detail
Functional
CHEMBL4254062
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Cytotoxicity against human BxPC3 cells after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.42 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290541 | — | — | 1 | 5.63 |
| CHEMBL4277892 | — | — | 1 | 5.60 |
| CHEMBL4293027 | — | — | 1 | 5.23 |
| CHEMBL4285825 | — | — | 1 | 5.21 |
| CHEMBL4282423 | — | — | 1 | - |
| CHEMBL4292641 | — | — | 1 | - |
| CHEMBL4284762 | — | — | 1 | - |
| CHEMBL1831157 | — | — | 1 | - |
| CHEMBL1830149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290541 | — | EC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4277892 | — | EC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL4293027 | — | EC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4285825 | — | EC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL4282423 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4292641 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4284762 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1831157 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1830149 | — | EC50 | > | 100000.0 | nM | - |