Assay Detail
Binding
CHEMBL4254481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate by colorimetric method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.33 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.30 |
| CHEMBL4279764 | — | — | 1 | 6.96 |
| CHEMBL4290032 | — | — | 1 | 6.80 |
| CHEMBL4279346 | — | — | 1 | 6.77 |
| CHEMBL4289748 | — | — | 1 | 6.75 |
| CHEMBL4285920 | — | — | 1 | 6.72 |
| CHEMBL4291092 | — | — | 1 | 6.62 |
| CHEMBL4287667 | — | — | 1 | 6.60 |
| CHEMBL4293133 | — | — | 1 | 6.57 |
| CHEMBL4291293 | — | — | 1 | 6.47 |
| CHEMBL4278472 | — | — | 1 | 6.43 |
| CHEMBL4279063 | — | — | 1 | 6.41 |
| CHEMBL4289328 | — | — | 1 | 6.36 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.31 |
| CHEMBL4288111 | — | — | 1 | 6.28 |
| CHEMBL4283242 | — | — | 1 | 6.28 |
| CHEMBL4277993 | — | — | 1 | 6.27 |
| CHEMBL4288714 | — | — | 1 | 6.25 |
| CHEMBL4283447 | — | — | 1 | 6.25 |
| CHEMBL4281944 | — | — | 1 | 6.25 |
| CHEMBL4291556 | — | — | 1 | 6.20 |
| CHEMBL4288146 | — | — | 1 | 6.19 |
| CHEMBL4277468 | — | — | 1 | 6.17 |
| CHEMBL4277617 | — | — | 1 | 6.17 |
| CHEMBL4277505 | — | — | 1 | 6.11 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 6.10 |
| CHEMBL4278057 | — | — | 1 | 6.08 |
| CHEMBL4286599 | — | — | 1 | 6.05 |
| CHEMBL4281448 | — | — | 1 | 6.05 |
| CHEMBL4285512 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4279764 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4290032 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4279346 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4289748 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4285920 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4291092 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4287667 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4293133 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4291293 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4278472 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4279063 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4289328 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4283242 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4288111 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4277993 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4288714 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4281944 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4283447 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4291556 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4288146 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4277468 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4277617 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4277505 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4278057 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4286599 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4281448 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4285512 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4289814 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4294497 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4285368 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4286390 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4293190 | — | IC50 | = | 1340.0 | nM | 5.87 |