Assay Detail
Binding
CHEMBL4254547
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Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.71 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291322 | — | — | 1 | 9.59 |
| CHEMBL4277476 | — | — | 1 | 9.26 |
| CHEMBL4285796 | — | — | 1 | 9.10 |
| CHEMBL4286174 | — | — | 1 | 8.96 |
| CHEMBL4278933 | — | — | 1 | 8.96 |
| CHEMBL4294077 | — | — | 1 | 8.64 |
| CHEMBL4288120 | — | — | 1 | 8.59 |
| CHEMBL4289783 | — | — | 1 | 8.48 |
| CHEMBL4289605 | — | — | 1 | 7.92 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291322 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL4277476 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL4285796 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL4286174 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4278933 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4294077 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4288120 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4289783 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4289605 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2104993 | VORTIOXETINE | Ki | = | 26.0 | nM | 7.58 |