Assay Detail
Functional
CHEMBL4254601
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.64 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.70 |
| CHEMBL4285846 | — | — | 1 | 8.52 |
| CHEMBL4287325 | — | — | 1 | 8.10 |
| CHEMBL4290690 | — | — | 1 | 8.10 |
| CHEMBL4285810 | — | — | 1 | 8.05 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.92 |
| CHEMBL4293724 | — | — | 1 | 7.68 |
| CHEMBL4290051 | — | — | 1 | 7.62 |
| CHEMBL4285231 | — | — | 1 | 7.51 |
| CHEMBL4284722 | — | — | 1 | 7.50 |
| CHEMBL4289671 | — | — | 1 | 7.44 |
| CHEMBL4292908 | — | — | 1 | 7.35 |
| CHEMBL4276677 | — | — | 1 | 7.27 |
| CHEMBL4282802 | — | — | 1 | 7.23 |
| CHEMBL4280283 | — | — | 1 | 7.20 |
| CHEMBL4283697 | — | — | 1 | 7.08 |
| CHEMBL4290325 | — | — | 1 | 6.98 |
| CHEMBL4286254 | — | — | 1 | 6.87 |
| CHEMBL4289588 | — | — | 1 | 6.76 |
| CHEMBL4286914 | — | — | 1 | 6.75 |
| CHEMBL4285297 | — | — | 1 | 6.69 |
| CHEMBL4277874 | — | — | 1 | 6.68 |
| CHEMBL4278308 | — | — | 1 | 6.64 |
| CHEMBL4277924 | — | — | 1 | 6.58 |
| CHEMBL4281794 | — | — | 1 | 6.47 |
| CHEMBL4277837 | — | — | 1 | 6.44 |
| CHEMBL4289248 | — | — | 1 | 6.39 |
| CHEMBL4285778 | — | — | 1 | 6.38 |
| CHEMBL4278193 | — | — | 1 | 6.19 |
| CHEMBL4292966 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4285846 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4290690 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4287325 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4285810 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4293724 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4290051 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4285231 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4284722 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4289671 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4292908 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4276677 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4282802 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4280283 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4283697 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4290325 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4286254 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4289588 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4286914 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4285297 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4277874 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4278308 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL4277924 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4281794 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4277837 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL4289248 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL4285778 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL4278193 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4292966 | — | IC50 | = | 1135.0 | nM | 5.95 |
| CHEMBL4285797 | — | IC50 | = | 1388.0 | nM | 5.86 |
| CHEMBL4289623 | — | IC50 | = | 1666.0 | nM | 5.78 |
| CHEMBL4278952 | — | IC50 | = | 2074.0 | nM | 5.68 |
| CHEMBL4294093 | — | IC50 | = | 2212.0 | nM | 5.66 |
| CHEMBL4278913 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4287277 | — | IC50 | = | 2472.0 | nM | 5.61 |
| CHEMBL4278990 | — | IC50 | = | 2988.0 | nM | 5.53 |
| CHEMBL4279350 | — | IC50 | = | 2995.0 | nM | 5.52 |
| CHEMBL4290466 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL4282374 | — | IC50 | = | 5257.0 | nM | 5.28 |
| CHEMBL4282446 | — | IC50 | = | 12080.0 | nM | 4.92 |
| CHEMBL4288191 | — | IC50 | = | 14490.0 | nM | 4.84 |
| CHEMBL4282770 | — | IC50 | = | 18030.0 | nM | 4.74 |
| CHEMBL4286191 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4289172 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4290659 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4294840 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4278336 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4278596 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4288576 | — | IC50 | > | 20000.0 | nM | - |