Assay Detail
Binding
CHEMBL4254604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig brain tubulin polymerization measured every 1 min for 20 mins by spectrophotometric method
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.44 | 5.77 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285846 | — | — | 2 | 5.77 |
| CHEMBL4285231 | — | — | 1 | 5.46 |
| CHEMBL4293724 | — | — | 2 | 5.46 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285846 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4285231 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4293724 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL107 | COLCHICINE | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4293724 | — | Inhibition | - | % | - | |
| CHEMBL4285846 | — | Inhibition | - | % | - |