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Assay Detail

CHEMBL4254751

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Bacillus pasteurii urease using urea as substrate measured after 20 mins by phenol reagent based assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sporosarcina pasteurii
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity.
Ullah A, Iftikhar F, Arfan M, Batool Kazmi ST, Anjum MN, Haq IU, Ayaz M, Farooq S, Rashid U.
Eur J Med Chem (2018) 145 : 140 -153
PubMed 29324337 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.68 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4291460 1 5.21
CHEMBL4289990 1 5.08
CHEMBL4280822 1 4.94
CHEMBL4278131 1 4.94
CHEMBL4288060 1 4.92
CHEMBL4285007 1 4.87
CHEMBL4277421 1 4.86
CHEMBL4288796 1 4.79
CHEMBL4281584 1 4.71
CHEMBL4287630 1 4.71
CHEMBL4288559 1 4.68
CHEMBL260876 THIOUREA 1 4.68
CHEMBL4292207 1 4.56
CHEMBL4292393 1 4.53
CHEMBL4277057 1 4.53
CHEMBL4282177 1 4.51
CHEMBL4279723 1 4.50
CHEMBL4284244 1 4.46
CHEMBL4288065 1 4.43
CHEMBL4288990 1 4.43
CHEMBL4278313 1 4.31
CHEMBL4294872 1 4.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4291460 IC50 = 6230.0 nM 5.21
CHEMBL4289990 IC50 = 8330.0 nM 5.08
CHEMBL4280822 IC50 = 11510.0 nM 4.94
CHEMBL4278131 IC50 = 11430.0 nM 4.94
CHEMBL4288060 IC50 = 11970.0 nM 4.92
CHEMBL4285007 IC50 = 13610.0 nM 4.87
CHEMBL4277421 IC50 = 13750.0 nM 4.86
CHEMBL4288796 IC50 = 16320.0 nM 4.79
CHEMBL4281584 IC50 = 19510.0 nM 4.71
CHEMBL4287630 IC50 = 19290.0 nM 4.71
CHEMBL4288559 IC50 = 21110.0 nM 4.68
CHEMBL260876 THIOUREA IC50 = 21000.0 nM 4.68
CHEMBL4292207 IC50 = 27440.0 nM 4.56
CHEMBL4292393 IC50 = 29310.0 nM 4.53
CHEMBL4277057 IC50 = 29530.0 nM 4.53
CHEMBL4282177 IC50 = 30980.0 nM 4.51
CHEMBL4279723 IC50 = 31340.0 nM 4.50
CHEMBL4284244 IC50 = 35100.0 nM 4.46
CHEMBL4288065 IC50 = 37290.0 nM 4.43
CHEMBL4288990 IC50 = 37010.0 nM 4.43
CHEMBL4278313 IC50 = 48600.0 nM 4.31
CHEMBL4294872 IC50 = 52410.0 nM 4.28