Assay Detail
ADMET
CHEMBL4254897
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Cytotoxicity against human PBMC cells assessed as inhibition of cell viability after 72 hrs by alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, anticancer activity and mechanism of action of new thiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.56 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.42 |
| CHEMBL4279709 | — | — | 1 | 4.37 |
| CHEMBL4294855 | — | — | 1 | 4.27 |
| CHEMBL4286552 | — | — | 1 | 4.18 |
| CHEMBL2369206 | — | — | 1 | 4.10 |
| CHEMBL4293246 | — | — | 1 | 4.03 |
| CHEMBL4284233 | — | — | 1 | - |
| CHEMBL4287619 | — | — | 1 | - |
| CHEMBL4286224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4279709 | — | IC50 | = | 43030.0 | nM | 4.37 |
| CHEMBL4294855 | — | IC50 | = | 53160.0 | nM | 4.27 |
| CHEMBL4286552 | — | IC50 | = | 65560.0 | nM | 4.18 |
| CHEMBL2369206 | — | IC50 | = | 80170.0 | nM | 4.10 |
| CHEMBL4293246 | — | IC50 | = | 93310.0 | nM | 4.03 |
| CHEMBL4284233 | — | IC50 | = | 150520.0 | nM | - |
| CHEMBL4287619 | — | IC50 | = | 130400.0 | nM | - |
| CHEMBL4286224 | — | IC50 | = | 139620.0 | nM | - |