Assay Detail
Functional
CHEMBL4255086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Caco2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining based HCS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of human immuno- and constitutive proteasomes inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.23 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237875 | — | — | 1 | 5.89 |
| CHEMBL4290574 | — | — | 1 | 5.30 |
| CHEMBL4294116 | — | — | 1 | 4.50 |
| CHEMBL2337849 | — | — | 1 | - |
| CHEMBL4280071 | — | — | 1 | - |
| CHEMBL4290977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237875 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4290574 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4294116 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2337849 | — | EC50 | - | — | - | |
| CHEMBL4280071 | — | EC50 | - | — | - | |
| CHEMBL4290977 | — | EC50 | - | — | - |