Assay Detail
Functional
CHEMBL4255087
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining based HCS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of human immuno- and constitutive proteasomes inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.61 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237875 | — | — | 1 | 6.57 |
| CHEMBL4290574 | — | — | 1 | 6.16 |
| CHEMBL4294116 | — | — | 1 | 5.05 |
| CHEMBL4290977 | — | — | 1 | 4.64 |
| CHEMBL2337849 | — | — | 1 | - |
| CHEMBL4280071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237875 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4290574 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4294116 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4290977 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2337849 | — | EC50 | - | — | - | |
| CHEMBL4280071 | — | EC50 | - | — | - |