Assay Detail
Binding
CHEMBL4255097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length human ASK1 expressed in HEK293/AP1-Luc cells assessed as reduction in p38 phosphorylation after 18 hrs by HTRF assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 5 (CHEMBL5285) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.97 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4294318 | — | — | 1 | 7.55 |
| CHEMBL4290518 | — | — | 1 | 7.39 |
| CHEMBL4289040 | — | — | 1 | 7.14 |
| CHEMBL4283739 | — | — | 1 | 7.08 |
| CHEMBL4282644 | — | — | 1 | 7.03 |
| CHEMBL4287097 | — | — | 1 | 6.85 |
| CHEMBL4279174 | — | — | 1 | 6.57 |
| CHEMBL4278211 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4294318 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4290518 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4289040 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4283739 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4282644 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4287097 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4279174 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4278211 | — | IC50 | = | 736.0 | nM | 6.13 |