Assay Detail
Functional
CHEMBL4255441
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Cytotoxicity against human A549 cells assessed as decrease in cell viability by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.78 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 8.70 |
| CHEMBL4292080 | — | — | 1 | 5.26 |
| CHEMBL4280765 | — | — | 1 | 4.73 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4292080 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4280765 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 36800.0 | nM | 4.43 |