Assay Detail
Functional
CHEMBL4255499
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Cytotoxicity against human HEY cells after 72 to 120 hrs by sulforhodamine B assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEY |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.99 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126916 | — | — | 1 | 6.24 |
| CHEMBL4291195 | — | — | 1 | 6.09 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 6.07 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126916 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4291195 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2700.0 | nM | 5.57 |