Assay Detail
Functional
CHEMBL4255506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SKOV3 cells after 72 to 120 hrs by sulforhodamine B assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.97 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126916 | — | — | 1 | 9.21 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 9.12 |
| CHEMBL4291195 | — | — | 1 | 8.94 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126916 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL4291195 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.39 | nM | 8.62 |