Assay Detail
Functional
CHEMBL4255507
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Cytotoxicity against vinblastine-resistant human SKVLB1 cells after 72 to 120 hrs by sulforhodamine B assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126916 | — | — | 1 | 7.12 |
| CHEMBL4291195 | — | — | 1 | 5.80 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 5.45 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126916 | — | IC50 | = | 75.6 | nM | 7.12 |
| CHEMBL4291195 | — | IC50 | = | 1578.0 | nM | 5.80 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 3533.0 | nM | 5.45 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 12590.0 | nM | 4.90 |