Assay Detail

CHEMBL4255509

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Functional

Cytotoxicity against human SKOV3 cells after 72 to 120 hrs in presence of verapamil by sulforhodamine B assay

ChEMBL ↗

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Target

SK-OV-3 (CHEMBL614925) ↗

Open DB target context

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SK-OV-3 (CHEMBL614925) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SK-OV-3

CHEMBL614925

Anchored from Assay target.

Protein identity SK-OV-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SK-OV-3
Confidence	1 — Organism
Curated By	Intermediate

Target

SK-OV-3 (CHEMBL614925) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.

Yang CH, Wang C, Ojima I, Horwitz SB.
J Nat Prod (2018) 81 : 600 -606
PubMed 29517223 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.62	8.84

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL126916	—	—	1	8.84
CHEMBL428647	PACLITAXEL	4.0	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL126916	—	IC50	=	1.44	nM	8.84
CHEMBL428647	PACLITAXEL	IC50	=	3.99	nM	8.40