Assay Detail
Functional
CHEMBL4255604
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.05 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.00 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.36 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.09 |
| CHEMBL4278900 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4278900 | — | IC50 | = | 17200.0 | nM | 4.76 |