Assay Detail
Binding
CHEMBL4255622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells at -40 mV holding potential measured after 600 secs by patch clamp method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 5 subunit alpha (CHEMBL1980) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acyl Sulfonamides NaV1.7 Blockers Useful for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.05 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287506 | — | — | 1 | 5.43 |
| CHEMBL4290933 | — | — | 1 | 5.42 |
| CHEMBL4294322 | — | — | 1 | 5.25 |
| CHEMBL4280298 | — | — | 1 | 5.19 |
| CHEMBL4276864 | — | — | 1 | 5.01 |
| CHEMBL4283748 | — | — | 1 | 4.82 |
| CHEMBL4279180 | — | — | 1 | 4.74 |
| CHEMBL4292013 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287506 | — | IC50 | = | 3697.0 | nM | 5.43 |
| CHEMBL4290933 | — | IC50 | = | 3818.0 | nM | 5.42 |
| CHEMBL4294322 | — | IC50 | = | 5673.0 | nM | 5.25 |
| CHEMBL4280298 | — | IC50 | = | 6508.0 | nM | 5.19 |
| CHEMBL4276864 | — | IC50 | = | 9666.0 | nM | 5.01 |
| CHEMBL4283748 | — | IC50 | = | 15105.0 | nM | 4.82 |
| CHEMBL4279180 | — | IC50 | = | 18347.0 | nM | 4.74 |
| CHEMBL4292013 | — | IC50 | = | 30000.0 | nM | 4.52 |