Assay Detail
Functional
CHEMBL4255708
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Antiviral activity against Influenza A virus (A/Hong Kong/68(H3N2)) infected in MDCK cells assessed as reduction in virus-induced cytopathic effect by crystal violet staining based light-microscopic analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Hong Kong/68(H3N2)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 8.70 |
| CHEMBL4277543 | — | — | 1 | 7.92 |
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.30 |
| CHEMBL4292664 | — | — | 1 | 6.35 |
| CHEMBL4284791 | — | — | 1 | 6.34 |
| CHEMBL3392935 | — | — | 1 | - |
| CHEMBL1235691 | — | — | 1 | - |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4277543 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL959 | RIMANTADINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4292664 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4284791 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3392935 | — | EC50 | - | — | - | |
| CHEMBL1235691 | — | EC50 | - | — | - | |
| CHEMBL660 | AMANTADINE | EC50 | - | — | - |