Assay Detail
Binding
CHEMBL4255799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In Search of the Optimal Macrocyclization Site for Neurotensin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.55 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415788 | — | — | 1 | 9.10 |
| CHEMBL4289739 | — | — | 1 | 6.40 |
| CHEMBL4279055 | — | — | 1 | 5.85 |
| CHEMBL4283301 | — | — | 1 | 5.77 |
| CHEMBL4286324 | — | — | 1 | 5.12 |
| CHEMBL4286652 | — | — | 1 | 5.00 |
| CHEMBL4294207 | — | — | 1 | 4.99 |
| CHEMBL4279408 | — | — | 1 | 4.84 |
| CHEMBL4291157 | — | — | 1 | 4.77 |
| CHEMBL4290088 | — | — | 1 | 4.70 |
| CHEMBL4284772 | — | — | 1 | 4.53 |
| CHEMBL4292651 | — | — | 1 | - |
| CHEMBL4294560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415788 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4289739 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4279055 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4283301 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4286324 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4286652 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4294207 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4279408 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4291157 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4290088 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4284772 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL4292651 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4294560 | — | IC50 | > | 100000.0 | nM | - |