Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4255801

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at GFP10-tagged human NTS1 expressed in CHO-K1 cells assessed as Rluc2-fused beta-arrestin2 recruitment after 20 mins by BRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neurotensin receptor type 1 (CHEMBL4123)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

In Search of the Optimal Macrocyclization Site for Neurotensin.
Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É.
ACS Med Chem Lett (2018) 9 : 227 -232
PubMed 29541365 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.86 5.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4289739 1 5.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4289739 EC50 = 1370.0 nM 5.86