Assay Detail
Binding
CHEMBL4255804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus Newman Hi6-tagged CrtN expressed in Escherichia coli BL21(DE3))/pET28a::CrtN assessed as reduction in staphyloxanthin levels using diapophytoene as substrate after overnight incubation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus str. Newman |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (CHEMBL3813586) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain Newman) |
Publication
Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.53 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284707 | — | — | 1 | 6.59 |
| CHEMBL4288408 | — | — | 1 | 6.57 |
| CHEMBL3827961 | — | — | 1 | 6.50 |
| CHEMBL4278050 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284707 | — | IC50 | = | 258.4 | nM | 6.59 |
| CHEMBL4288408 | — | IC50 | = | 270.4 | nM | 6.57 |
| CHEMBL3827961 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4278050 | — | IC50 | = | 340.7 | nM | 6.47 |