Assay Detail
Binding
CHEMBL4255805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CrtN in vancomycin-intermediate Staphylococcus aureus Mu50 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus Mu50 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (CHEMBL4105905) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain Mu50 / ATCC 700699) |
Publication
Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.05 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827961 | — | — | 1 | 9.30 |
| CHEMBL4284707 | — | — | 1 | 8.92 |
| CHEMBL4278050 | — | — | 1 | 8.92 |
| CHEMBL4288408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827961 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4284707 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4278050 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4288408 | — | IC50 | < | 0.1 | nM | - |